Global Institute for Water Security

Academic Background

  • Ph.D. (Biology), RWTH Aachen University, Germany
  • M.Sc. (Ecotoxicology), RWTH Aachen University, Germany
  • B.Sc. (Biology), RWTH Aachen University, Germany

Research Expertise and Interests

Markus Brinkman's research in exposure and risk assessment modelling focuses on uptake and effects of contaminants in aquatic organisms under realistic exposure scenarios. What is the influence of environmental and physiological factors and how can we predict these? How do findings from the lab translate to the field situation? What are the relevant parameters in the field, e.g. during flood events or as a result of global change? To answer these and other questions, Brinkmann use computational models that are informed by experimental data and combine knowledge from different fields, including toxicology, environmental chemistry, and hydrology.

Research Keywords

  • Exposure and Risk Assessment Modelling
  • Toxicokinetic Modelling
  • Aquatic Ecotoxicology


Apenova, N., Peng, H., Hecker, M., Brinkmann, M. (2018) A rapid and sensitive fluorometric method for determination of aldehyde oxidase activity. Toxicology and Applied Pharmacology 341: 30-37.

Brinkmann, M., Hecker, M., Giesy, J.P., Jones, P.D., Ratte, H.T., Hollert, H., Preuss, T.G. (2018) Generalized concentration addition accurately predicts estrogenic potentials of mixtures and environmental samples containing partial agonists. Toxicology in Vitro 46: 294-303.

Crawford, S. E., Cofalla, C, Aumeier, B., Brinkmann, M., Classen, E., Esser, V., Ganal, C., Kaip, E., Häussling, R., Lehmkuhl, F., Letmathe, P., Müller, A.-K., Rabinovitch, I., Reicherter, K., Schwarzbauer, J., Schmitt, M., Stauch, G., Wessling, M., Yüce, S., Hecker, M., Kidd, K. A., Altenburger, R., Brack, W., Schüttrumpf, H., Hollert, H. (2017) Project house water: a novel interdisciplinary framework to assess the environmental and socioeconomic consequences of flood-related impacts. Environmental Sciences Europe 29(1): 23.

Koch, J., Bui, T., Lundström Belleza, E., Brinkmann, M., Hollert, H., Breitholtz, M. (2017) Temperature and food quantity effects on the harpacticoid copepod Nitocra spinipes: Combining in vivo bioassays with population modeling. PLoS ONE 12(3): e0174384. doi:10.1371/journal.pone.0174384

Brack, W., Dulio, V., Ågerstrand, M., Allan, I., Altenburger, R., Brinkmann, M., Bunke, D., Burgess, R.M., Cousins, I., Escher, B.I., Hernández, F.J., Hewitt, L.M., Hilscherová, K., Hollender, J., Hollert, H., Kase, R.,Klauer, B., Lindim, C., López Herráeza, D., Miègen, C., Munthe, J., O'Toole, S., Posthuma, L., Rüdel, H., Schäfer, R.B., Sengl, M., Smedes, F., van deMeent, D., van den Brink, P.J., van Gils, J., van Wezel, A.P., Vethaak, A.D., Vermeirssen, E., von der Ohe, P.C., Vrana, B. (2016) Towards the review of the European Union Water Framework management of chemical contamination in European surface water resources. Science of the Total Environment 576 (2017) 720–737

U., Hollert, H., Brinkmann, M., Eichbaum, K., Weber, R., Salomons, W. (2016) Dioxin in the Elbe river basin: policy and science under the water framework directive 2000–2015 and toward 2021. Environmental Sciences Europe 28:9.

Eichbaum, K., Brinkmann, M., Nuesser, L., Buchinger, S., Reifferscheid, G., Codling, G., Jones, P., Giesy, J.P., Hecker, M., Hollert, H. (2016) Bio-analytical and instrumental screening of the uptake of sediment-borne, dioxin-like compounds in roach (Rutilus rutilus). Environmental Science and Pollution Research, DOI 10.1007/s11356-016-6377-y.

Brinkmann, M., Schlechtriem, C., Reininghaus, M., Eichbaum, K., Buchinger, S., Reifferscheid, G., Hollert, H., Preuss, T.G. (2016) Cross-Species Extrapolation of Uptake and Disposition of Neutral Organic Chemicals in Fish Using a Multispecies Physiologically-Based Toxicokinetic Model Framework. Environmental Science and Technology 50:1914–1923.

Schiwy, A. & Brinkmann, M., Thiem, I., Guder, G., Winkens, K., Eichbaum, K., Nüßer, L., Thalmann, B., Buchinger, S., Reifferscheid, G., Seiler, T.-B., Thoms, B., Hollert, H. (2015) Determination of the dioxin-like potential of single substances, complex mixtures and environmental samples in the Micro-EROD assay with H4IIE cells. Nature Protocols 10, 1728–1741.

Brinkmann, M., Eichbaum, K., Reininghaus, M., Koglin, S., Kammann, U., Baumann, L., Segner, H., Zennegg, M., Buchinger, S., Reifferscheid, G., Hollert, H. (2015): Towards science-based sediment quality standards for dioxin-like compounds – effects of field-collected sediments in rainbow trout (Oncorhynchus mykiss). Aquatic Toxicology 166:50-62.

Brinkmann, M., Freese, M., Pohlmann, J.-D., Kammann, U., Preuss, T.G., Buchinger, S., Reifferscheid, G., Beiermeister, A., Hanel, R., Hollert, H. (2015): A physiologically based toxicokinetic (PBTK) model for moderately hydrophobic organic chemicals in the European eel (Anguilla anguilla). Science of the Total Environment 536:279-287.

Lundström-Belleza, E., Brinkmann, M., Preuss, T.G., Breitholtz, M. (2014) Population-level effects in Amphiascus tenuiremis: Contrasting matrix- and individual-based population models. Aquatic Toxicology157:207-214.

Brinkmann, M., Eichbaum, K., Kammann, U., Hudjetz, S., Cofalla, C., Buchinger, S., Reifferscheid, G., Schüttrumpf, H., Preuss, T., Hollert, H. (2014) Physiologically-based toxicokinetic models help identifying the key factors affecting contaminant uptake during flood events. Aquatic Toxicology 152:38-46.

Brinkmann, M., Eichbaum, K., Buchinger, S., Reifferscheid, G., Bui, T., Schaeffer, A., Hollert, H., Preuss, T.G. (2014) Understanding receptor-mediated effects in rainbow trout: in vitro-in vivo extrapolation using physiologically based toxicokinetic models. Environmental Science and Technology 48:3303-3309.

Hudjetz, S., Herrmann, H., Cofalla, C., Brinkmann, M., Kammann, U., Schäffer, A., Schüttrumpf, H., Hollert, H. (2013) An attempt to assess the relevance of flood events—biomarker response of rainbow trout exposed to resuspended natural sediments in an annular flume. Environmental Sciences and Pollution Research, DOI: 10.1007/s11356-013-2414-2.

Kathrin Eichbaum, K., Brinkmann, M., Buchinger, S., Hecker, M., Engwall, M., van Bavel, B., Reifferscheid, G., Hollert, H. (2013) The dioRAMA project: assessment of dioxin-like activity in sediments and fish (Rutilus rutilus) in support of the ecotoxicological characterization of sediments. Journal of Soils and Sediments 13:770-774.

Brinkmann, M. & Hudjetz, S., Kuckelkorn, J., Yu, T., Cofalla, C., Roger, S., Kammann, U., Schüttrumpf, H., Hollert, H. (2013) How flood events affect rainbow trout: Evidence of a biomarker cascade in rainbow trout after exposure to PAH contaminated sediment suspensions. Aquatic Toxicology 128-129: 13-24.

Cofalla, C., Hudjetz, S., Roger, S., Brinkmann, M., Frings, R., Wölz, J., Schmidt, B., Schäffer, A., Kammann, U., Hecker, M., Hollert, H., Schüttrumpf, H. (2012) A combined hydraulic and toxicological approach to assess re-suspended sediments during simulated flood events—part II: an interdisciplinary experimental methodology. Journal of Soils and Sediments, DOI 10.1007/s11368-012-0476-2